Wednesday, 3rd August ANZBMS-MEPSA-ANZORS 2022

• Regulation of blood-brain barrier by a subset of astrocytes that express osteocyte marker DMP-1 - Delin Liu
• Identification of epigenetic factors deregulated in skeletal stem cells during high fat/glucose mediated inhibition of bone formation. - Ensieh Hajimotallebi
• The osteoinductive potential of the nutrient inorganic components from the bone microenvironment for in situ bone tissue engineering - Yuqing Mu
• Automated Grading System of Radiographic Knee Osteoarthritis Severity Using Deep Learning - Dinh-Tan Nguyen
• Pathogen-associated molecular patterns produced by infectious microbes worsen Neurogenic Heterotopic Ossifications after spinal cord injury - Selwin Gabriel Samuel
• Clinical cardiovascular disease and long-term falls risk: The Perth Longitudinal Study of Ageing in Women - Abadi Kahsu Gebre
• Poor alignment of a smaller femur with the upper body may contribute to increased fracture risk in women with POI - Navira Samad
• Elevated bone-derived sclerostin in plasma is associated with high brain amyloid-β load in cognitively normal older adults - Jun Yuan
• Changes in body composition are associated with incident vertebral deformities over 10.7 years - Anuj Shah
• Associations of Mechanical Loading from Physical Activity with Bone Mineral Density, Physical Function and Knee Impairment in Older Adults: the Tasmanian Older Adult Cohort (TASOAC) Study - Carrie-Anne Ng

• Ex vivo assessment of surgically repaired tibial plateau fracture displacement under axial load using large-volume micro-CT - Kieran J Bennett
• Development of predictive statistical shape models for paediatric lower limb bones - Beichen Shi
• Anterior lift-off of implanted press-fit tibial tray during deep knee bend: a time-elapsed micro-CT and digital volume correlation analysis. - Lauren S Wearne
• Histological characterisation of different tendons of the human hand - Samantha A Hefferan
• Examination of the interaction of autophagy and antibiotics in Staphylococcus aureus persistent infection of osteocytes - Nicholas J Gunn

Chair: Scott Byrne

• Bone microenvironment regulation of tumour outgrowth - Michelle M McDonald
• Bioengineering solutions for articular cartilage regeneration - Claudia Di Bella
• The ATP-P2X7 signalling axis in graft-versus-host disease: Recent insights from humanised mouse studies - Ronald Sluyter

• Transient lipodystrophy protects against high-fat diet-induced bone volume loss in male mice - Emma J Buckels
• Multimorbidity compounds excess mortality following proximal fractures: A nationwide cohort study - Thach Tran
• Osteocytes regulate organismal senescence of bone and bone marrow - Ming-Hao Zheng
• Spatially resolving the bone marrow microenvironment in MGUS and multiple myeloma   - Melissa D Cantley

1:40 PM     Topic 1. Welcome from the Sponsor
                   Dr Tiffany Bamford, Kyowa Kirin Australia Medical Affairs

1:43 PM     Introductions & learning objectives from the Chair
                  Prof Peter Ebeling (Chair), Head Dept of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences

                  Topic 2. X-Linked Hypophosphataemia

1:45 PM     XLH: Looking back, looking forward
                 Prof Craig Munns, Head of Mayne Academy of Paediatrics and Director of Child health Research Centre, University of Queensland; Paediatric Endocrinologist, Queensland Children’s Hospital.

                 Topic 3: Introducing CRYSVITA® (burosumab) - a new treatment option for XLH

1:50 PM     The safety and efficacy of CRYSVITA® in paediatrics
                  Prof Craig Munns, Head of Mayne Academy of Paediatrics and Director of Child health Research Centre, University of Queensland; Paediatric Endocrinologist, Queensland Children’s Hospital.

1:58 PM    The safety and efficacy of CRYSVITA® in adults
                Dr Syndia Lazarus, Endocrinologist, Queensland Health

                Panel Discussion

2:06 PM   The practical use of CRYSVITA® in Australia
                Prof Peter Ebeling, Prof Craig Munns & Dr Syndia Lazarus

2:18pm    Close
               Prof Peter Ebeling (Chair)

Lunch boxes provided for attendees of this session outside of Room 7.

• Transitioning adolescents with Osteogenesis Imperfecta to adult care: challenges and opportunities - Jenny Harrington
• Transition services for bone health in adolescents and young adults - Anne Trinh

• Geometry and bone mineral density determinants of femoral neck strength changes following exercise - Dermot O'Rourke
• What impact have therapeutic advances for musculoskeletal health had on mortality risk – do we see differential relationships for muscle and bone? - Elaine M Dennison
• Association Between Lifestyle Factor and Bone Loss in Elderly Women - Ngoc Huynh
• A 6-month digital health osteoporosis self-management intervention delivered via Amazon Alexa improved osteoporosis knowledge and falls self-efficacy in postmenopausal women with osteoporosis - David Scott
• An individualized approach for assessing change in bone mineral density - Tuan V Nguyen

Chair Geoffrey Handsfield

• All models are wrong, but some are useful: The challenge of model complexity for orthopaedic application - Thor Besier
• Finite element modelling to predict femoral fractures in transfemoral amputees with osseointegrated implants - Ryan Tiew
• Three-dimensional kinematics of the jaw following unilateral and bilateral prosthetic TMJ surgery - Sarah Woodford
• Overload-induced extracellular mitochondria releasing from tendon organoid leads to inflammation - Ziming Chen
• Lumbar spinal canal occlusion due to bulging of intervertebral disc - Dale L Robinson
• A pipeline to morph the finite element model of lumbar spine - Yihang Yu
• Surgical outcomes following tibialis anterior tendon transfer for recurrent congenital talipes equinovarus (CTEV). - Alexis Brierty
• A nonlinear controller algorithm to design a self-paced treadmill based on the real-time center of mass data - Hossein Mokhtarzadeh

• Mucosal protein-based vaccination with a TLR2-stimulating adjuvant induces potent local immunity against SARS-CoV-2 in mice - Anneliese s Ashhurst
• High-dimensional spatial analysis of the tumour-microenvironment to determine metastatic disease progression and response and resistance to therapy.   - Angela L Ferguson
• Tuft cells regulate inflammation in the lung during influenzaA virus infection - Jacqueline Marshall
• Local and systemic effects of narrowband UVB irradiation in mice  - Rachael A Ireland

• Artificial Intelligence Based Diagnostic Software for Atypical Femur Fractures  - Hanh H Nguyen
• Variance in Estimated Strength Along the Femoral Neck and Radius is Accounted for Differences in Macro- and Micro-architecture, not Bone Mass - Ali Ghasem-Zadeh
• Association between automated abdominal aortic calcification 24 scoring obtained from lateral spine images with long-term fracture risk: the Perth Longitudinal Study of Ageing Women - Marc Sim
• Agreement and associations between bone variables assessed via standard and high-resolution peripheral quantitative computed tomography - Jakub Mesinovic
• Contribution of local density variation to micro-finite element analysis in pediatric HR-pQCT - Andrew J Burghardt

• Translational Orthopaedics from the Perspective of an Academic Surgeon - Ross Crawford
• Development of a patient specific workflow for the corroboration of FE models with clinical migration data: A case study of the implanted acetabulum - Stuart Callary
• Sex differences in a pre-clinical model of injury-induced osteoarthritis - Sanaa Zaki
• Can RSA measurements predict long-term acetabular implant loosening earlier than the current two-year time point? - Chan Hee Cho
• Evaluating the effectivity of treatment options for intracellular S. aureus infections in osteomyelitis - Anja R Zelmer
• The Increased Hospital Cost of Treating Septic Revision Total Hip Arthroplasty - Aaron Hammat

• Making personalization of cancer treatment a reality with Spatial transcriptomics - Jazmina L Gonzalez-Cruz
• Development of a novel compound for the treatment of SCC in organ transplant recipients - James W Wells
• Is there a role for regulatory T cells in the establishment of Cutaneous Squamous Cell Carcinoma? - Shoaib Anwaar