Tuesday, 2nd August ANZBMS-MEPSA-ANZORS 2022

7:30 AM  Belinda Beck
The role of high intensity supervised exercise intervention in osteoporosis therapy.

7:55 AM Madhuni Herath
A local (ANZ) perspective on the management of primary hyperparathyroidism.

8:20 AM Richard Prince
The  pharmaceutical prescription for prevention of fracture in Australia 2022.

• Emerging approaches to investigate musculoskeletal health from HR-pQCT imagery   - Andrew Burghardt
• VFA's: You "aorta" look beyond vertebral fractures. - Joshua Lewis
• AI-driven image classification of radiographic data for prospective fracture prediction – global state and current work at the I²Lab. - Timo Damm

• Bisphosphonates may boost immune responses to pulmonary infection by acting on tissue-resident macrophages in the lung - Michael J Rogers
• Treating osteoporosis and dementia with anti-dementia medication acetylcholinesterase inhibitors may have therapeutic benefits on osteoporotic bone by attenuating osteoclastogenesis and bone resorption - Charles Inderjeeth
• Endothelial cells require mitochondrial transfer from osteocytes to promote vascularization in cortical bone - Ming-Hao Zheng
• Epidemiology of fractures in different ethnic groups across the lifespan in New Zealand - Brya Matthews
• Fracture risk in women with osteoporosis treated with gastro-resistant (ec) risedronate versus immediate release risedronate or alendronate: a claims data analysis in the United States - John Eisman

• Estradiol increases bone mass and strength in a pre-clinical mouse model of male-to-female transition during adulthood - Tian Nie

• RANKL discovery: a model for basic science research? - David Findlay
• Sugar transporter Slc37a2 regulates bone metabolism via a dynamic tubular lysosomal network in osteoclasts - Amy Ribet
• Structural and cellular characterisation of the osteochondral tissue in hip and knee osteoarthritis. - Dzenita Muratovic
• Strain Distributions Within the Proximal Tibia Calculated Using Digital Volume Correlation of Micro-CT Images - Kieran J Bennett
• Functional group differences in the biomechanical and biochemical properties of human hand tendons - Carina Blaker

Chair: Dr Cherie Chiang

Prof Jackie Center
Endocrinologist, Garvan Institute of Medical Research, St Vincent’s Hospital, Sydney

Clinical Prof Charles Inderjeeth
Rheumatologist & Geriatrician, North Metropolitan Health Service and University of Western Australia, Perth

Melissa Cantley

Supported by

• EphrinB2 and lysosomes in osteocytes are essential for collagen arrangement in the extracellular matrix - Martha Blank
• MicroRNA cargo of extracellular vesicles released by skeletal muscle negatively regulates the bone quality in obese mice - Ahmed AA Al Saedi
• Identifying genes involved in hip osteoarthritis and describing the cells in which they are differentially expressed - Kaitlyn A Flynn
• Skeletal glucocorticoid signalling plays a critical role in bone loss driven by circadian rhythm disruption - Eugenie Macfarlane
• Asymptomatic vertebral fractures predict subsequent clinical fracture in both men and women - Ruth Frampton
• Identification of asymptomatic vertebral fracture using Artificial Intelligence (AI) - Huy G Nguyen
• Bayesian Network Meta-Analysis of All-Cause Mortality in Trials of Osteoporosis Therapies - Alexander H Seeto
• A low serum alkaline phosphatase may signal the presence of hypophosphatasia in patients with reduced bone mineral density or fragility fractures - Elisabeth Ng

• Patients on dialysis are at lower risk for mortality when treated with non-calcium-based phosphate binders. - Grahame J Elder
• The proportion of patients who reach the BMD surrogate threshold effect on romosozumab: a post hoc analysis of the randomised FRAME and ARCH phase 3 trials - Jeffrey Hassall

• Fabrication of bio-textile collagen rope for ACL regeneration  - Peilin Chen
• Comparative Effects of Surgical And Non-Surgical Therapy on Hip Contact Force For Femoroacetabular Impingement Syndrome - Azadeh Nasseri
• Intervertebral disc-on-a-chip: a precision-engineered platform for low back pain studies - Javad Tavakoli

• On stem cell therapy for osteoarthritis: An in vitro investigation to explain clinical outcomes - Jiao Jiao Li
• Vertebral Body Tethering Functions as an Internal Brace for Patients with Adolescent Idiopathic Scoliosis - Megan J Roser

• Mechanical effects of semitendinosus tendon harvesting on knee function - William S du Moulin
• Stribeck curves of cartilage-on-cartilage shearing: a comparison of healthy versus mildly degenerate tissue - Ashvin Thambyah
• A six-dimensional envelope to describe failure in an amputated femur with an osseointegrated implant under external loads - Hans A Gray

• Harnessing peptide-based therapy to control inflammatory disease - Scott N Byrne
• Immunomodulatory human peptide RP23 alleviates atopic dermatitis-like inflammation in an oxazolone-induced murine model of disease - Jack W Rawlings
• Understanding CD8⁺ T cell killing mechanisms in UV-induced tumour models - Zhen Zeng
• Targeting hematoma regulation via platelet membrane coating for advanced clot-immunomodulation - Wendong Gao
• The effects of GCSF in human and murine osteoclast differentiation and mature function models - Rouha MS Granfar

• Understanding the burden of disease for those living with X-Linked Hypophosphatemia: a consumer perspective. - Sandy Bevc
• Fall prevention – how to translate into client management of bone health - Anne-Marie Hill

• Understanding the burden of disease for those living with X-Linked Hypophosphatemia: a consumer perspective - Craig F Munns
• Mice lacking ephrinB1 in the osteogenic lineage display craniomaxillofacial abnormalities - Agnieszka Arthur
• Lupus patients have increased fracture risk, recurrent fracture risk and 5 year mortality - Charles Inderjeeth
• Gram negative bacterial infections drive neurogenic heterotopic ossification after spinal cord or brain injury in mice and humans - Kylie A Alexander
• A case of hypophosphatasia treated with asfotase alfa - Liyan Wang

• Bioengineering humanized bone microenvironment models for cancer research applications. - Nathalie Bock
• Wearable sensors show differences in functional outcomes between robotic and conventional total knee arthroplasty - Faseeh Zaidi
• Comparing statistical shape modelling and contralateral mirroring in regenerating hemipelvis surface geometry - Praveen Krishna
• Gold Nanocluster-induced Immunomodulation for Tissue regeneration via Mitophagy Regulation: A Perspective on Materiobiology - Lan Xiao
• Translation from bench to bedside: testing a novel antimicrobial bone allograft in a standard rabbit distal femoral defect model - Katrina Browne

• Skin and bones: systemic mastocytosis and osteoporosis - Mawson Wang
• The RANK-L’s with Polyostotic Fibrous Dysplasia Treatment in Adulthood - Emma Croker
• An unusual cause of hypercalcemia in two siblings - Lucy Collins
• Multiple vertebral fractures in a patient with severe COVID-19 treated with lung transplantation - Louise S Goodall
• Diagnostic dilemma: progressive femoral lesion in a young woman - Christopher Preston
• A RUNX1 germline mutation as a novel cause of previously unexplained severe osteoporosis in a young male - Tomasz J Block