The formation of hematoma, particularly the fibrin network and fibrin network-mediated early inflammatory responses, plays a pivotal role in determining the eventual tissue repair or regeneration after an injury. Due to the critical role of the interplay between the fibrin network and immune response, it is of great significance to modulate the parameters of the fibrin network to achieve a favourable hematoma-immune response. Since platelets are involved in hematoma formation and can specifically bind to fibrinogen through its surface protein, and calcium ions play an important role in fibrin fibre growth and lateral aggregation, the platelet membrane was coated on the bioactive glass to modulate the fibrin formation process. The as-prepared platelet membrane-coated bioactive glass (PBG) is introduced as fibrinogen polymerization nuclei through specific binding and modulates the subsequent fibrin formation process through ion release. The PBG could reduce the coagulation time and increase fibre thickness and network porosity. Importantly, the PBG-modulated fibrin network shows a faster degradation rate with higher growth factor release from the fibrin network, which further supports the migration, proliferation, and differentiation of infiltrated macrophages. Besides, the PBG-modulated fibrin network the production of pro-inflammatory cytokines by macrophages through potential signaling pathways of fibrinolysis-immunomodulation and efferocytosis. In conclusion, the successful regulation of the clot-immune responses through advanced engineering of nanoparticles indicates the feasibility of developing novel clot-immune regulatory materials.